European Journal of Clinical Pharmacy

Volume 18 - Issue 3, May-June 2016

SHORT REPORTS

DRESS SYNDROME SECONDARY TO SIMEPREVIR FOR THE TREATMENT OF HEPATITIS C: A CASE REPORT

GARCÍA MAYO MARÍA ENCINA, VÁZQUEZ BLANCO SILVIA, VEIGA VILLAVERDE ANA BELÉN, CRESPO DIZ CARLOS

The term Drug Reaction (rash) with Eosinophilia and Systemic Symptoms (DRESS) is used to describe a severe Adverse Drug Reaction (ADR) with a mortality rate of approximately 10%. Both the morphology of the skin lesions and the degree of systemic involvement vary among patients, and their onset implies the need to
discontinue the suspected drug and administer corticotherapy. The present paper describes the case of a patient receiving treatment with simeprevir (SMV), pegylated interferon alpha-2a (PEG-INF) and ribavirin (RBV), who developed skin lesions, pruritus, rash, fever, eosinophilia, thrombocytopenia, lymphopenia, as well as frontal and periocular edemas, after 12 weeks of treatment. The patient was diagnosed with a DRESS syndrome based on regiSCAR (European Registry of Severe Cutaneous Adverse Reactions) criteria and on the skin biopsy performed. Treatment with topical corticoids was consequently initiated and SMV was subsequently discontinued, achieving gradual improvement of the patient’s clinical and haematological symptomatology.

SIMEPREVIR – DRESS SYNDROME – HEPATITIS C

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